Process for chiral synthesis of (2S,6R)-2,6-dialkyl piperidine hydrochloride
Title：
Process for chiral synthesis of (2S,6R)-2,6-dialkyl piperidine hydrochloride
Application Number：
 200410083625
Application Date：
 2004/10/13
Announcement Date：
 2005/07/06
Pub. Date：
 2006/12/13
Publication Number：
 1634887
Announcement Number：
 1289480
Grant Date：
 2006-12-13
Granted Pub. Date：
 2006-12-13
ApplicationType：
 Invention
State/Country：
 11[China|beijing]
IPC：
 C07D 211/10
Applicant(s)：
 Tsinghua University
Inventor(s)：
 Hu Yuefei, Wang Xinyan, Dong Yanmei
Key Words：
 chiral synthesis, (2S,6R)-2,6-dialkyl piperidine hydrochloride
Abstract：
 The invention discloses a method for chiral synthesis of (2S, 6R)-2,6-dialkyl piperidine hydrochloride. The synthesis process comprises the following steps: (1) 1-(alpha-amino benzyl)-2-naphthol reacts with 1,5-glutaraldehyde and benzotriazole to produce compound V; (2) the compound V from step(1) reacts with organic metal reagent to produce compound VI at -78C.-20C.; (3) the compound VI from step(2) reacts with organic metal reagent to produce compound VII at -10C.-20C.; (3) in the presence of dichloromethane, the compound VII from step(3) is catalytically hydrocracked to produce (2S,6R)-2,6-dialkyl piperidine hydrochloride.
Claim：
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