Method for covalent grafting heparin on surface of polymer film |
Title： |
| Method for covalent grafting heparin on surface of polymer film |
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Application Number： |
200410009002 |
Application Date： |
2004/04/05 |
Announcement Date： |
2005/01/12 |
Pub. Date： |
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Publication Number： |
1563157 |
Announcement Number： |
1246372 |
Grant Date： |
2006-3-22 |
Granted Pub. Date： |
2006-3-22 |
ApplicationType： |
Invention |
State/Country： |
11[China|beijing] |
IPC： |
C08J 7/16, C08L 5/10 |
Applicant(s)： |
Tsinghua Univ. |
Inventor(s)： |
Zhang Yong, Feng Qingling, Cui Fuzhai |
Key Words： |
polymer film, surface, covalent grafting, heparin |
Abstract： |
The method is featured as washing and extracting polymer film by alcohol, placing it in ammonium persulfate aqueous solution for forming peroxide perssad with activation initiating polymerization of vinyl monomer containing carboxy on surface by ferrisulphas ammonium, converting carboxyl to be end azyl by using 1-ethyl-3-(3-dimethyl propyl) EDC as cross-linking agent to react with a,W-aminopropyl-polyglycol and fixing heparin on polymer film surface by covalent bond through condensation of carboxyl and azyl in heparin structure. |
Claim： |
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Priority： |
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PCT： |
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LegalStatus： |
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