Thiophosphoryl amino acid ester compound and its prepn process
Title：
Thiophosphoryl amino acid ester compound and its prepn process
Application Number：
 01130784
Application Date：
 2001/08/24
Announcement Date：
 2002/02/27
Pub. Date：
Publication Number：
 1337401
Announcement Number：
 1159332
Grant Date：
 2004-7-28
Granted Pub. Date：
 2004-7-28
ApplicationType：
 Invention
State/Country：
 11[China|beijing]
IPC：
 A61P 31/12, A61P 31/18, A61P 35/00, C07H 19/06, C07H 19/10
Applicant(s)：
 Qinghua Univ.
Inventor(s)：
 Zhao Yufen, Miao Zhiwei, Fu Hua
Key Words：
 Thiophosphoryl amino acid ester compound, prepn process
Abstract：
 The present invention relates to a thiophosphoryl amino acid ester compound. Said invention provides its structural formula, and its preparation method incldues the following steps: dissolving raw material (isopropoxy substituted) dichlorthion in tetrahydrofuran, adding amino acid methyl ester hydrochlorate to said solution, drop-adding acid-binding agent, and adding 2',3'-O-isopropylidene nucleoside solution in said solution, then more drop-adding acid-binding to make reaction, after reaction filtering, rotating distrillation, column chromatography to make separation, so that the invented compound can be obtained.
Claim：
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PCT：
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