Preparation method of liposome with high encapsulating rate to water soluble medicine
Title：
Preparation method of liposome with high encapsulating rate to water soluble medicine
Application Number：
 200410096075
Application Date：
 2004/11/29
Announcement Date：
 2005/07/06
Pub. Date：
 2006/08/23
Publication Number：
 1633990
Announcement Number：
 1270698
Grant Date：
 2006-8-23
Granted Pub. Date：
 2006-8-23
ApplicationType：
 Invention
State/Country：
 11[China|beijing]
IPC：
 A61K 9/127, A61K 47/24
Applicant(s)：
 Tsinghua University
Inventor(s)：
 Jiang Guoqiang, Zhu Dequan, Zan Jia
Key Words：
 Preparation method, liposome, high encapsulating rate, water soluble medicine
Abstract：
 The invention relates to a preparation method of liposome with high encapsulating rate to water soluble medicine, wherein the process is based on reversed phase evaporation method and comprises the steps of, (1) charging solvent into natural or synthesized phosphatides and adjunct, obtaining gel form grease containing lipid substance and medicament to be sealed through reversed phase evaporation method, quitting evaporation solvent, (2) placing the obtained gel form grease into electric field with constant current strength, slowly charging grease form solution into the system, removing the small amount of organic solvent in the system through nitrogen purging, (3) homogenizing the liposome through probe type supersound so as to obtain nano liposome.
Claim：
Priority：
PCT：
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  Selected patents owned by Tsinghua University filed in 2005 are loaded.
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