Glutamine synthetase and its dedicated expression engineered bacteria and uses
Title：
Glutamine synthetase and its dedicated expression engineered bacteria and uses
Application Number：
 200610089484
Application Date：
 2006/06/29
Announcement Date：
 2006/12/27
Pub. Date：
Publication Number：
 1884501
Announcement Number：
Grant Date：
Granted Pub. Date：
ApplicationType：
 Invention
State/Country：
 11[China|beijing]
IPC：
 C12N 9/00, C12N 15/52, C12N 1/21, C12P 13/02, C12R 1/19
Applicant(s)：
 Tsinghua University
Inventor(s)：
 Cao Zhuan, Huang Xing, Liu Ming
Key Words：
 Glutamine synthetase, dedicated expression, engineered bacteria, uses
Abstract：
 The invention discloses a glutamine synthetase and its special-purpose expression project bacterium and its allocation, which is to provide a glutamine synthetase and its special-purpose expression project bacterium and its allocation. The said glutamine synthetase is prepared by abrupt change of the 405th amino acid residue of amino end to phenylalanine corynebacterium glutamicum. The engineering bacteria prepare the recombination bacteria by importing the recombination expression carrier containing the said glutamine synthetase gene into host bacteria. The glutamine synthetase produced by the engineering bacteria can specially act on NH4+ and aminoglutaric acid, the durability to the high concentration ammonium ion has been distinctively improved because of the dissolution of adenosine acylation modification, the major bottleneck of glutamine with enzymatical production has been solved, and the concentration of the obtained glutamine can reach 47.6g/L. The invention has higher practicability and flackery and has wide application foreground in glutamine commercial manufacture.
Claim：
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PCT：
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