Method for screening SARS coronaviruses main Protease inhibitors from natural product such as Chinese medicinal materials mixture prepared storeroom
Title：
Method for screening SARS coronaviruses main Protease inhibitors from natural product such as Chinese medicinal materials mixture prepared storeroom
Application Number：
 200710065119
Application Date：
 2007/04/04
Announcement Date：
 2007/10/31
Pub. Date：
Publication Number：
 101063234
Announcement Number：
Grant Date：
Granted Pub. Date：
ApplicationType：
 Invention
State/Country：
 12[China|tianjin]
IPC：
 C40B 30/04, G01N 33/573
Applicant(s)：
 Nankai University
Inventor(s)：
 Rao Zihe, Sun Yuna, Lou Zhiyong, Xiang Kehui
Key Words：
 screen,SARS coronaviruses,main Protease inhibitors,natural product,Chinese medicinal materials
Abstract：
 The invention discloses a method to sieve SARS coronavirus main prolease depressor from natural products mixture optional warehouse, which comprises the following steps: touching crystal of SARS coronavirus main prolease with 'sample with inhibited active'; getting electron density of small molecule depressant combined with SARS coronavirus main prolease; appraising the small molecule depressant based on electron density; getting fine three-dimensional structure of SARS coronavirus main prolease and small molecule depressant; getting small molecule depressant Sichuan scented sea vegetable ala factor. This Sichuan scented sea vegetable ala factor can inhibit coronavirus main prolease activator effectively, which can cure or prevent SARS coronavirus and infectivity gastrointestinal disease virus.
Claim：
Priority：
PCT：
LegalStatus：

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2008-4-17
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