New method for screening HCV-NS5B protein inhibitor from Chinese herb medicines natural products mixture alternate library
Title：
New method for screening HCV-NS5B protein inhibitor from Chinese herb medicines natural products mixture alternate library
Application Number：
 200710065245
Application Date：
 2007/04/09
Announcement Date：
 2007/11/07
Pub. Date：
Publication Number：
 101067213
Announcement Number：
Grant Date：
Granted Pub. Date：
ApplicationType：
 Invention
State/Country：
 12[China|tianjin]
IPC：
 C40B 30/04, A61K 36/30, A61P 31/12, A61P 1/16
Applicant(s)：
 Nankai Univ.
Inventor(s)：
 Rao Zihe, Sun Yuna, Lou Zhiyong, Zhang Chang
Key Words：
 screen,HCV-NS5B protein inhibitor,Chinese herb medicines, natural products mixture,alternate library
Abstract：
 The present invention provides new method of screening HCV NS5B protein inhibitor from candidate library of natural product mixtures. HCV NS5B protein crystal is made to contact with sample with inhibiting activity to obtain complex crystal of HCV NS5B protein and small molecular inhibitor. The small molecular inhibitor combined with HCV NS5B protein is identified based on the electronic density of the small molecular inhibitor, so as to obtain fine 3D structure of the complex of HCV NS5B protein and small molecular inhibitor. In this way, acetylshikonin as small molecular HCV NS5B protein inhibitor is screened out. Acetylshikonin may be used in preparing medicine for preventing and treating HCV infection.
Claim：
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