Function and application of MAAT1p15 antigen correlated to melanoma |
Title： |
| Function and application of MAAT1p15 antigen correlated to melanoma |
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Application Number： |
200410102875 |
Application Date： |
2004/12/29 |
Announcement Date： |
2006/07/05 |
Pub. Date： |
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Publication Number： |
1796410 |
Announcement Number： |
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Grant Date： |
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Granted Pub. Date： |
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ApplicationType： |
Invention |
State/Country： |
11[China|beijing] |
IPC： |
C07K 14/435,C07K 14/47,C12N 15/63,C12N 5/16,A61K 38/17,A61P 35/00,G01N 33/68, G01N 33/574, C12Q 1/68 |
Applicant(s)： |
Beijing Tencher''s Univ. |
Inventor(s)： |
Han Liang, Huang Shisi, Zhang Xinjun, Wang Fang, Zhang Hui, Zhai Yonggong, Chang Zhijie |
Key Words： |
Function, application, MAAT1p15, antigen correlated, melanoma |
Abstract： |
This invention publishes the function of melanoma-associated antigen MAAT1p15 (melanoma-associated antigen recogmzed by cytotoxic T lymphocytes p15). It derivatively comprises an amino acid residue sequence of SEQ ID No.1 within which one or several amino acid residues is substituted, deleted or added and performs the same activities as those of SEQ ID No.1. Yeast two-hybrid identification implemented with the intracellular domain of LRP6 as bait protein, the interaction between MAAT1p15 and LRP6 is identified and further confirmed in mammalian cells. Results from luciferase report system also reveals that MAAT1p15 significantly enhances the transcription activity of Wnt1 and LRP6-responsive downstream genes, and such a synergetic activation is promoted with an increasing transfection amount of MAAT1p15. Therefore, it is quite probable that MAAT1p15 participates in the signal pathway of Wnt through interaction with LRP6 and thus helps receptor LRP6 with signal conduction. The identification of the function of MAAT1p15 provides new clues for investigating the signal conduction mechanism of Wnt and establishes a new base for further elucidating the molecular mechanisms of the emergence and development of melanoma. |
Claim： |
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PCT： |
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