Interleukin-17 acceptor, and its coding gene and application |
Title： |
| Interleukin-17 acceptor, and its coding gene and application |
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Application Number： |
200510115181 |
Application Date： |
2005/11/14 |
Announcement Date： |
2006/04/12 |
Pub. Date： |
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Publication Number： |
1757651 |
Announcement Number： |
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Grant Date： |
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Granted Pub. Date： |
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ApplicationType： |
Invention |
State/Country： |
11[China|beijing] |
IPC： |
C07K 14/705, C07H 21/04, C12N 15/24, C12N 5/10, G01N 33/68 |
Applicant(s)： |
Tsinghua Univ. |
Inventor(s)： |
Liu Li, Li Tieshi, Li Xueni, Fu Xinyuan, Chang Zhijie, Zhang Shuping |
Key Words： |
Interleukin-17 acceptor, coding gene, application |
Abstract： |
This invention discloses an acceptor of inferleukin 17 and its code and their application, the objective is to provide an acceptor of inferleukin 17 and its code gene and their application of preparing mark substance for diagnose tumour and treatment medicine for RAS/MAPK signal access related diseases. The albumen is a protein with following one of the sequence of amino-acid residue radical: 1) SEQ ID ¡í£º2 in sequence table; 2) amino-acid residue radical sequence in SEQ ID ¡í£º2 in the sequence table are replaced by one to ten of amino-acid residue radical, lose or added and through activating RAS/MAPK signal access and with promoting karyokinesis action protein. inferleukin 17 acceptorof this invention will play a important roll in diagnose tumor, since its code gene mIL-17RE interferes the code gene of RNA, it can be used as active component to prepare medicine, for treatment diseases related to RAS/MAPK signal access, such as prostate tumour, leukaemia and thyroid gland tumour and other diseases. The invention has more practical meaning and wide application prospect in medical science and biological pharmacy field. |
Claim： |
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Priority： |
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PCT： |
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