Production of tetrodotoxin by microbiological fermentation
Title：
Production of tetrodotoxin by microbiological fermentation
Application Number：
 200510002904
Application Date：
 2005/01/26
Announcement Date：
 2005/10/12
Pub. Date：
Publication Number：
 1680567
Announcement Number：
Grant Date：
Granted Pub. Date：
ApplicationType：
 Invention
State/Country：
 11[China|beijing]
IPC：
 C12P 17/18, C12N 1/20
Applicant(s)：
 Qinghua Univ.
Inventor(s)：
 Zhang Rongqing, Xie Liping, Wang Shujin, Hu Jiangchun, Wu Zhenlong, Ma Yuandong, Zhang Jinfang
Key Words：
 microbiological fermentation, production, tetrodotoxin
Abstract：
 A process of preparing tetrodotoxin using microbial ferment technology from ocean actinomyces that can producTTX separated from red-fin dolphin. It contains shake ferment, batchwise hemicontinuous ferment and continuous ferment. Continuous ferment can last for 1 month. Centrifugate zymotic fluid and decolourize using activated carbon. Elute stripper column with acetic acid solution. Concentrate and freeze dry. The purified product can be reached.
Claim：
Priority：
PCT：
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  Selected patents owned by Tsinghua University filed in 2005 are loaded.
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