Production method of 7-amino cephalosporanic acid |
Title： |
| Production method of 7-amino cephalosporanic acid |
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Application Number： |
200410039573 |
Application Date： |
2004/02/10 |
Announcement Date： |
2004/12/29 |
Pub. Date： |
2006/10/18 |
Publication Number： |
1557962 |
Announcement Number： |
1280423 |
Grant Date： |
2006-10-18 |
Granted Pub. Date： |
2006-10-18 |
ApplicationType： |
Invention |
State/Country： |
11[China|beijing] |
IPC： |
C12P 35/02 |
Applicant(s)： |
Tsinghua University |
Inventor(s)： |
Luo Hui, Shen Zhongyao, Li Qiang |
Key Words： |
Production method, 7-amino cephalosporanic acid |
Abstract： |
The production process of 7-amino cefaphytanic acid includes the following steps: culturing and collecting free cell with D-amino acid oxidase and glutaryl-7-amino cefaphytanic acid acylatase activity; and suspending in pH 7.0-8.0 buffering solution, adding 1-5 % concentration cephalosporin C solution, reaction at 20-35 deg.c for 200-600 min to obtain 7-amino cefaphytanic acid. By means of the combination of free cell catalysis and membrane, the present invention has simplified 7-amino cefaphytanic acid producing process and apparatus, raised enzyme utilization, and lowered production cost. The present invention has obvious predominance and excellent industrial application foreground. |
Claim： |
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Priority： |
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PCT： |
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LegalStatus： |
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