Neutral and variable sites of cytomembrane protein M2 of influenza virus and their use
Title：
Neutral and variable sites of cytomembrane protein M2 of influenza virus and their use
Application Number：
 200410046103
Application Date：
 2004/05/31
Announcement Date：
 2005/02/23
Pub. Date：
 2006/07/05
Publication Number：
 1583785
Announcement Number：
 1262563
Grant Date：
 2006-7-5
Granted Pub. Date：
 2006-7-5
ApplicationType：
 Invention
State/Country：
 11[China|beijing]
IPC：
 C07K 7/06, A61K 38/08, A61P 31/16
Applicant(s)：
 Tsinghua Univ.
Inventor(s)：
 Chen Yinghua, Liu Wanli, Lu Yun
Key Words：
 Neutral, variable sites, cytomembrane protein M2, influenza virus, use
Abstract：
 This invention relates to influenza virus cytomembrane protein M2 whose neutralizing epitope and variant epitope, and its applications. The neutralizing epitope thereof has octapeptide of amino acid residue sequence in sequence map's sequence 1; the variant epitope is selected from one of octapeptides of below amino acid residue sequences: (1) sequence 2 's amino acid residue sequence of the sequence map; (2) sequence 3 's amino acid residue sequence of the sequence map; (3) sequence 4 's amino acid residue sequence of the sequence map. The Hybridoma technique is used to obtain the mono-clone antibody 8C6 (subtype IgG2a) which is aimed at influenza virus M2 cellula albuminosa outside area's neutralizing epitope. The Balb/C small rat, through passive immunizing with mono-clone antibody 8C6, resists the attack of influenza virus. The mono-clone has well protecting and treating effect. The influenza virus cytomembrane protein M2 's neutralizing epitope and variant epitope will be more important to cure influenza and prevent from it.
Claim：
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2008-4-17
  Selected patents owned by Tsinghua University filed in 2005 are loaded.
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