VEGF expression-inhibiting siRNA and application thereof
Title:
VEGF expression-inhibiting siRNA and application thereof
Application Number:
200510130094
Application Date:
2005/12/12
Announcement Date:
2006/07/19
Pub. Date:
Publication Number:
1804038
Announcement Number:
Grant Date:
Granted Pub. Date:
ApplicationType:
Invention
State/Country:
94[China|shenzhen]
IPC:
C12N 15/11, C07H 21/00, A61K 48/00, A61P 35/00
Applicant(s):
Graduate School at Shenzhen, Tsinghua University
Inventor(s):
Zhang Yao''u, Cai Guoping, Jiang Yuyang, He Yonghong
Key Words:
VEGF expression-inhibiting, siRNA, application
Abstract:
The siRNA as VEGF-siRNA -2-deoxy1 or VEGF-siRNA-2-deoxy2 with its application to restrain VEGF is disclosed in this invention. Wherein, the VEGF-siRNA -2-deoxy1 comprises a sense chain with the nucleotide sequence as SEQ ID No.3 and anti-sense chain with the sequence as SEQ ID No.4; while another one comprises a sense chain with the nucleotide sequence as SEQ ID No.5 and anti-sense chain with the sequence as SEQ ID No.6; both two former compounds have long half-life hard to be degraded, fit to external experiment even the internal treatment, and can restrain the tumor, such as cervical cancer, liver cancer, breast cancer and lung cancer.
Claim:
Priority:
PCT:
LegalStatus:

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2008-4-17
  Selected patents owned by Tsinghua University filed in 2005 are loaded.
2008-3-31
  Selected patents owned by Tsinghua University filed in 2006 and 2007 are load.







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