Fusion protein capable of removing HPV E7 protein and its encoding gene and application
Title:
Fusion protein capable of removing HPV E7 protein and its encoding gene and application
Application Number:
200710117817
Application Date:
2007/06/25
Announcement Date:
2008/01/09
Pub. Date:
Publication Number:
101100487
Announcement Number:
Grant Date:
Granted Pub. Date:
ApplicationType:
Invention
State/Country:
94[China|shenzhen]
IPC:
C07K 19/00C12N 15/62A61K 38/16A61K 48/00A61P 35/00
Applicant(s):
Graduate School at Shenzhen, Tsinghua University
Inventor(s):
Ji Yanhong, Zhang Yaou
Key Words:
Fusion protein, encoding gene, application, HPV E7 protein
Abstract:
A fusion protein for eliminating HPV E7 protein, its encoding gene and its use are disclosed. The fusion protein contains (1) or (2) protein, human F-box protein structural domain and human RB protein A-B box structural domain. The process is carried out by: substituting fusion protein amino-acid residue sequence with one or multi-amino acid residues and/or losing and/or adding, and eliminating protein derived from (1) in HPV E7. The fusion protein and/or the fusion-protein encoding gene, and/or recombinant expression carrier containing fusion protein encoding gene can be used to eliminate HPV E7 protein, prepare medicines in prevention and/or treatment HPV infection.
Claim:
Priority:
PCT:
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2008-4-17
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